7703 Floyd Curl Drive San Antonio, TX 78229

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Yi Zhu, PhD
Assistant Professor, Associate Consultant
Department of Physiology and Biomedical Engineering
Mayo Clinic College of Medicine and Science

Title: "Cellular senescence and senolytics in aging and diseases,"

Summary: Dr. Yi Zhu earned her BS from Beijing Normal University, followed by a PhD from the University of Michigan. She completed her postdoctoral training under the mentorship of Dr. James Kirkland at the Mayo Clinic, where she later joined the faculty in the Department of Physiology and Biomedical Engineering. Now an assistant professor at Mayo Clinic, Dr. Zhu is renowned for her groundbreaking work on cellular senescence.

Her research primarily focuses on how senescent cells drive age-related diseases and neurological disorders. Among her significant achievements is the discovery of the first generation of senolytics in 2015, which has shown great promise in preclinical trials for mitigating age-associated dysfunction. Currently, Dr. Zhu’s research targets senescent glial cells and explores the role of peripheral senescent cells in brain aging and Alzheimer's disease. She also utilizes cutting-edge spatial-OMICs techniques to map senescent cells in human diseased tissues, advancing the understanding of cellular senescence in age-related pathologies.

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